本工作采用离子交换剂双管钙离子选择性微电极测量大鼠大脑皮层细胞外钙离子浓度,并记录了青霉素诱发的癫痫发作过程中皮层不同深度细胞外钙离子浓度的动态变化。在正常大鼠大脑皮层,细胞外钙离子浓度为1.3～1.4mM,癫痫发作过程中钙离子浓度降低到1.1～1.2mM。当皮层表面记录到散发的癫痫波时,在皮层表面以下720μm深处钙离子浓度的动态变化最大,约0.2mM。实验初步结果对阐明实验性癫痫发病机理有一定的意义。 In this work, ion exchangers double-tube calcium-selective microelectrode was used to measure extracellular calcium concentration in the cerebral cortex of rats and the dynamic changes of extracellular calcium concentration in different depths of cortex during penicillin-induced seizures were recorded. In the normal rat cerebral cortex, the extracellular calcium concentration was 1.3-1.4 mM, and the calcium concentration decreased to 1.1-1.2 mM during the seizure. When the epidermis wave was recorded on the surface of the cortex, the calcium concentration at the depth of 720 μm below the surface of the cortex had the largest dynamic change of about 0.2 mM. Preliminary results of the experiment to clarify the experimental pathogenesis of epilepsy has a certain significance.