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头孢菌素类抗生素已成为当今治疗感染的重要药物。随着临床的广泛使用，对其产生的不良反应——“戒酒硫样反应”，已日益引起临床的关注。“戒酒硫”即双硫醒（disulfram； antabuse），化学名称是双（二乙基硫代氨甲酰）二硫化物，是人们熟知的一种治疗慢性酒精中毒、酒精中毒性精神病的药物。当患者接受戒酒硫后，再饮用乙醇即可出现戒酒硫样反应。主要症状是面红、血压下降、胸闷、心跳加快、呼吸困难、失神、头痛、恶心、呕吐、眼花、恍惚、错乱、心律紊乱、痉挛等。近年来报道，有些头孢菌素也可引起类似反应。
Cephalosporins have become an important drug in the treatment of infections today. With the widespread use of clinical, the side effects of its reaction - “alcohol-like sulfur-like reaction,” has increasingly attracted clinical attention. “Sulfur disulfide” is a disulframide (antabuse), the chemical name is bis (diethyl thiocarbamoyl) disulfide, is a well-known drug for the treatment of chronic alcoholism, alcoholic mental illness . When patients receive alcohol-abstinence, alcohol-drinking can lead to the withdrawal of the sulfur-like reaction. The main symptoms are redness, blood pressure, chest tightness, rapid heartbeat, dyspnea, absence, headache, nausea, vomiting, vertigo, trance, confusion, cardiac disorders, spasms and so on. In recent years, some cephalosporins also cause similar reactions.