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目的比较促性腺激素释放激素激动剂(GnRHa)短方案与促性腺激素释放激素拮抗剂(GnRH-ant)方案对体外授精-胚胎移植(IVF-ET)高龄卵巢储备功能下降(DOR)患者的临床疗效。方法选择2014年1月-2016年6月在海南医学院附属医院生殖中心行IVF-ET的高龄DOR患者213个周期,其中采用短方案87个周期,拮抗剂方案126个周期。比较两组患者的一般资料、临床效果及结局(获卵数、2PN、MⅡ卵子数、可移植胚胎、优质胚胎数、周期取消率及临床妊娠率)。结果两组患者的一般资料无显著差异(P>0.05)。两组的获卵数、2PN、MⅡ卵数、可移植胚胎、优质胚胎数、周期取消率及生化妊娠率均无显著差异(P>0.05),但拮抗剂方案组临床妊娠率显著高于短方案组,差异具有统计学意义(P<0.05)。结论对IVF-ET的高龄DOR患者,采用拮抗剂治疗方案的疗效优于短方案。
Objective To compare the clinical efficacy of GnRHa short protocol and GnRH-ant regimen in elderly patients with ovarian reserve loss (DOR) after IVF-ET (IVF-ET) Efficacy. METHODS: From January 2014 to June 2016, 213 cycles of advanced DOR with IVF-ET in the Affiliated Hospital of Hainan Medical College were enrolled. Among them, 87 cycles were short and 126 cycles were used as antagonist. The general data, clinical effect and outcome (number of retrieved oocytes, 2PN, MII oocytes, transferable embryos, number of high quality embryos, cycle cancellation rate and clinical pregnancy rate) were compared between the two groups. Results There was no significant difference in general data between the two groups (P> 0.05). There were no significant differences in the number of retrieved oocytes, 2PN, MII oocytes, transferable embryos, number of high quality embryos, cycle cancellation rate and biochemical pregnancy rate (P> 0.05). However, the clinical pregnancy rates of the two groups were significantly higher than those of the short Program group, the difference was statistically significant (P <0.05). CONCLUSIONS: Antagonists are superior to shorter regimens in the treatment of advanced DOR in patients with IVF-ET.