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目的研究少弱精子症及无精子症患者细胞染色体异常及染色体多态性的发生情况。方法对341例男性不孕不育患者(弱精子症165例,少精子症34例,重度少精子症44例,少弱精子症79例,无精子症19例)的外周血淋巴细胞进行培养、制片及G显带染色体核型分析。结果染色体异常27例,异常率7.9%。常染色体异常为16例,异常率为4.7%;性染色体异常11例,异常率为3.2%。染色体异常率弱精子症占3.0%,少精子症占5.8%,重度少精子症占18.1%,少弱精子症占6.3%,无精子症占36.8%。染色体多态性变异61例,占17.8%。结论男性不孕不育患者染色体异常和多态性发生率明显较高,对该类患者有必要常规做染色体检查,尤其在实施辅助生殖技术之前,以避免将遗传缺陷传递给下一代。
Objective To study the occurrence of chromosomal abnormalities and chromosomal polymorphisms in oligoasthenospermia and azoospermia patients. Methods Peripheral blood lymphocytes of 341 male infertility patients (165 cases of asthenospermia, 34 cases of oligozoospermia, 44 cases of severe oligospermia, 79 cases of oligozoospermia, 19 cases of azoospermia) were cultured , Producer and G-banding karyotype analysis. Results Chromosomal abnormalities in 27 cases, the abnormal rate of 7.9%. An autosomal abnormality was 16 cases, the abnormal rate was 4.7%; 11 cases of sex chromosome abnormalities, the abnormal rate was 3.2%. Chromosomal abnormalities accounted for 3.0% of poor sperm disease, oligospermia accounted for 5.8%, severe oligozoospermia accounted for 18.1%, less weak sperm accounted for 6.3%, azoospermia accounted for 36.8%. Chromosome polymorphism in 61 cases, accounting for 17.8%. Conclusion The incidence of chromosomal abnormalities and polymorphisms in male infertility patients is significantly higher. It is necessary for these patients to routinely do chromosomal examination, especially before implementing assisted reproductive technology so as to avoid passing genetic defects to the next generation.