造血干细胞是造血重建的主要来源,而移植低温保存的骨髓、外周血造血干细胞治疗辐射损伤、再生障碍性贫血、综合免疫缺陷病、淋巴瘤等患者均有较好疗效。但同种异体移植易引起严重移植物抗宿主病(GVHD)。人们对胎肝细胞和自体骨髓移植寄予很大希望,它不仅可获得满意的造血重建,而且避免了GVHD的发生。目前冷冻保存技术已成为造血干细胞移植的一个重要组成部分。 Hematopoietic stem cells are the main source of hematopoietic reconstitution, and transplantation of cryopreserved bone marrow, peripheral blood stem cell therapy for radiation injury, aplastic anemia, combined immunodeficiency disease, lymphoma and other patients have a good effect. However, allografts are likely to cause severe graft-versus-host disease (GVHD). People have great hopes for fetal liver cells and autologous bone marrow transplantation, it can not only get satisfactory hematopoietic reconstitution, but also avoid the occurrence of GVHD. Cryopreservation techniques have become an important part of hematopoietic stem cell transplantation.