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烷化剂通常与其他药物联合治疗结节性分化差淋巴细胞淋巴瘤(NLPD),其缓解较为迅速,但缓解率和生存期并不优于单一制剂。联合治疗常产生秃发、全血细胞减少、神经系统毒性症状和恶心、呕吐等毒性反应。为了观察应用单一烷化剂间歇治疗能否减轻毒性而不降低疗效,作者对18例Ⅲ或Ⅳ期NLPD患者给予大剂量间歇口服瘤可宁治疗,剂量为16mg/M~2/d,每月连续5天,共12疗程。
Alkalisers are often combined with other drugs in the treatment of poorly differentiated lymphoplastic lymphoma (NLPD), the more rapid response, but the response rate and survival is not better than a single preparation. Combination therapy often produces alopecia, pancytopenia, neurotoxic symptoms and nausea, vomiting and other toxic reactions. In order to observe whether intermittent treatment with a single alkylating agent can reduce the toxicity without decreasing the curative effect, we treated 18 patients with stage III or IV NLPD with high dose intermittent oral neopheniramine at a dose of 16 mg / M ~ 2 / d every month For 5 consecutive days, a total of 12 courses.