有机硝酸酯经代谢形成无机亚硝酸盐,后者将血红蛋白氧化成高铁血红蛋白,过量的高铁血红蛋白可引起高铁血红蛋白血症。临床实验剂量的有机硝酸酯虽可引起高铁血红蛋白含量增加,但一般无临床意义。几例病例报告描述了接受硝酸甘油(iv)剂量>10μg/kg·min 时,高铁血红蛋白含量有很大增加。由于目前可行的临床试验设计的缺点,现在难以确定剂量-反应关系,特别是用口服和舌下给药有机硝酸酯治疗时。根据Saxon 和 Organic nitrates are metabolized to form inorganic nitrite, which oxidizes hemoglobin to methemoglobin, and excess methemoglobin causes methemoglobinemia. Although the clinical trials of organic nitrate may cause methemoglobin content increased, but generally no clinical significance. Several case reports have reported a significant increase in methaemoglobin content with nitroglycerin (iv) doses> 10 μg / kg · min. Due to the shortcomings of currently available clinical trial designs, it is now difficult to determine the dose-response relationship, especially when treated with oral and sublingual nitrates. According to Saxon and