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目的探讨血浆同型半胱氨酸水平与脑梗死的关系。方法 138例脑梗死患者(脑梗死组),根据是否合并高血压分为高血压合并脑梗死组107例和单纯脑梗死组31例;62例健康对照者(对照组),检测研究血浆同型半胱氨酸(Hcy)、叶酸(FA)、维生素B12等指标。结果脑梗死组的血浆同型半胱氨酸水平(18.15±4.23)μmol/L显著高于对照组(10.02±2.52)μmol/L,差异有统计学意义(P<0.01);血浆同型半胱氨酸水平与叶酸和维生素B12均呈负相关;高血压脑梗死患者的同型半胱氨酸水平高于单纯脑梗死患者,差异有统计学意义(P<0.01)。结论同型半胱氨酸是脑梗死的一个重要发病因素,血浆同型半胱氨酸水平与叶酸和维生素B12均呈负相关,高同型半胱氨酸血症与高血压性脑梗死有关。
Objective To investigate the relationship between plasma homocysteine level and cerebral infarction. Methods A total of 138 patients with cerebral infarction (cerebral infarction group) were divided into two groups according to whether they had hypertension or not: 107 patients with cerebral infarction complicated by hypertension and 31 patients with cerebral infarction; 62 healthy controls (control group) Cystine (Hcy), folic acid (FA), vitamin B12 and other indicators. Results The level of plasma homocysteine (18.15 ± 4.23) μmol / L in cerebral infarction group was significantly higher than that in control group (10.02 ± 2.52) μmol / L, the difference was statistically significant (P <0.01) The level of acid was negatively correlated with folic acid and vitamin B12. Homocysteine level in patients with hypertensive cerebral infarction was significantly higher than that in patients with simple cerebral infarction (P <0.01). Conclusion Homocysteine is an important causative factor in cerebral infarction. Plasma homocysteine level is negatively correlated with folic acid and vitamin B12. Hyperhomocysteinemia is associated with hypertensive cerebral infarction.