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目的探讨免疫相关性全血细胞减少症(immunorelated pancytopenia,IRP)区别于再生障碍性贫血(aplastic anemia,AA)临床诊断依据及预后意义。方法 2005年1月至2006年12月对江西省吉水县人民医院14例 IRP 患者及10例 AA 患者的血像、骨髓像以及实验室相关检查及疗效分析。结果 IRP 与 AA 外周血象均为三系细胞减少,但 IRP 网织红细胞(Ret)不低,骨髓象粒、红比例不低,巨核细胞数不少,骨髓增生不均一应区别与 AA。IRP 临床疗效优于 AA。结论区分 IRP 与 AA 有益于临床诊断及预后判断,其诊断标准有待完善。
Objective To investigate the clinical diagnosis basis and prognostic significance of immunorelated pancytopenia (IRP) differing from that of aplastic anemia (AA). Methods From January 2005 to December 2006, 14 cases of IRP patients and 10 cases of AA patients in Jishui People ’s Hospital of Jiangxi Province were examined by blood and bone marrow as well as laboratory related tests and curative effects. Results IRP and AA peripheral blood were all three-line cells decreased, but the IRP reticulocyte (Ret) is not low, bone marrow particles, red ratio is not low, a large number of megakaryocytes, myeloid hyperplasia should be distinguished with AA. The clinical efficacy of IRP is better than AA. Conclusion The distinction between IRP and AA is good for clinical diagnosis and prognosis, and the diagnostic criteria need to be improved.