光与某些药物和化学制剂相结合时,能产生两大类皮肤光敏感反应,即光变态反应和光毒性反应.光变态反应为免疫学机理的介导,符合变态反应性过敏的标准.光毒性反应引起的细胞损伤的机理尚有待阐明.业已提出的一种机理是细胞膜的过氧化作用.此种概念是基于在原卟啉(PP)的存在下,以 Light, when combined with certain drugs and chemicals, produces two broad categories of skin photoreactive reactions, phototropism and phototoxicity, which are mediated by immunological mechanisms and meet the criteria for allergic hypersensitivity. Light The mechanism of cell damage caused by toxic reactions remains to be elucidated. One mechanism that has been proposed is the peroxidation of the cell membrane. This concept is based on the idea that in the presence of protoporphyrin (PP)