胰性脑病(pancreatic encephalopathy,PE)是重症急性胰腺炎(severe acute pancreatitis,SAP)的严重并发症,其病情凶险,进展快,病死率高,临床治疗较为困难。近年来,对其诊断及治疗有所提高,其预后也显著改善,但临床上仍有颇多问题并未解决,有待深入研究。本文就PE的诊治进展综述如下。1 PE发病机制1.1胰酶激活在SAP患者中,由于胰腺坏死,大量由胰腺 Pancreatic encephalopathy (PE) is a serious complication of severe acute pancreatitis (SAP). The disease is dangerous, rapidly progressed and has a high case fatality rate. It is difficult to treat with clinical treatment. In recent years, its diagnosis and treatment have increased, and its prognosis has also been significantly improved, but there are still many clinical problems have not been solved, pending further study. This article on the diagnosis and treatment of PE are summarized below. 1 PE pathogenesis 1.1 pancreatic enzyme activation in SAP patients, due to pancreatic necrosis, a large number of pancreatic