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实验选用雌性狗,每五只一组,皮下注射黄体酮共74周。开始12周注射剂量为0.083,0.25或0.75毫克/公斤/天,以后24周注射剂量为0.83,2.5或7.5毫克/公斤/天,自37～74周注射剂量为2.5、7.5或22.5毫克/公斤/天。结果表明:在试验期内,除注射0.083毫克/公斤的两只动物外都没有出现动情期,实验组及单独注射辅形剂的对照组在注射部位均出现慢性炎症。此外,实验组动物呈现体重、血浆胆固醇及血糖量均超过正常幅度,子宫体发生显著变化,内膜腺体增生,卵巢的卵泡成熟受到抑制,垂体出现大量嗜酸细胞。在
Female dogs were selected experimentally, and every five mice were injected subcutaneously with progesterone for 74 weeks. Injecting doses of 0.083, 0.25 or 0.75 mg / kg / day for the first 12 weeks and 0.83, 2.5 or 7.5 mg / kg / day for the subsequent 24 weeks and 2.5, 7.5 or 22.5 mg / kg from 37 to 74 weeks /day. The results showed that during the experimental period, no estrous period was observed except for the two animals injected with 0.083 mg / kg. The experimental group and the control group injected with auxin alone had chronic inflammation at the injection site. In addition, animals in the experimental group showed body weight, plasma cholesterol and blood glucose levels were beyond the normal range, significant changes in the uterus, endometrial glandular hyperplasia, ovarian follicular maturation was inhibited, a large number of pituitary eosinophils. in