作者将环烷酮与苯甲醛在醇钠中缩合制成α,α′-二亚苄基环烷酮,然后以钯炭为触媒还原成α,α′-二苄基环烷酮,并进行了降低血胆固醇的活性试验。试验结果以反式2,8-二苄基环辛酮最为有效。大白鼠口服或腹腔注射的ED_(50)为10毫升/公斤/天,用药后可降低血胆固醇50%,比安妥明强10～20倍,而且作用迅速,5毫克/公斤剂量时,24小时即生效。 2,8-二苄基环辛酮在1～50毫克/公斤范围内可抑止体重增加,故有可能作为治疗肥胖症的药物。降低血胆固醇及体重的作用均属可逆,停药后即趋正常,体重的上升比血 The authors of cycloalkanone and benzaldehyde condensation in sodium alcoholate α, α’-dibenzylidene cycloalkanone, and then palladium on carbon catalyst was reduced to α, α’-dibenzyl cycloalkanone, and To reduce blood cholesterol activity test. The test results with trans 2,8-dibenzyl cyclooctanone most effective. Oral or intraperitoneal injection of ED_ (50) in rats was 10 ml / kg / day, after treatment can reduce blood cholesterol by 50%, 10 ~ 20 times stronger than clofibrate, and the role of rapid, 5 mg / kg dose, 24 hours Effective. 2,8-dibenzyl cyclooctanone inhibits weight gain in the range of 1 to 50 mg / kg, making it possible to treat obesity. Reduce the role of cholesterol and body weight are reversible, normal after withdrawal, weight gain than blood