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目的分析二甲双胍对妊娠期糖尿病孕妇妊娠结局及新生儿的影响。方法选取2013年12月-2015年12月在该院就诊的妊娠期糖尿病孕妇120例为本次的观察对象,采取计算机随机分组法分为对照组与观察组,每组各60例。对照组采用胰岛素进行治疗,观察组在此基础上加用二甲双胍进行治疗,比较两组孕妇的妊娠结局及对新生儿的影响。结果治疗前两组孕妇血糖水平比较差异无统计学意义(P>0.05),治疗后观察组孕妇血糖控制明显优于对照组(P<0.05),观察组孕妇血糖控制率为91.67%,对照组为46.67%(P<0.05);观察组孕妇妊娠并发症、新生儿低血糖、新生儿黄疸发生率明显低于对照组(均P<0.05)。结论二甲双胍联合胰岛素治疗妊娠期糖尿病,能够有效改善血糖各项指标,同时还能够改善妊娠结局,值得临床推广应用。
Objective To analyze the effect of metformin on pregnancy outcome and newborns in gestational diabetic patients. Methods A total of 120 pregnant women with gestational diabetes admitted to our hospital from December 2013 to December 2015 were selected as the observation subjects and randomly divided into control group and observation group with 60 cases in each group. The control group was treated with insulin. The observation group was treated with metformin on this basis. The pregnancy outcome and the effect on the newborn in the two groups were compared. Results There was no significant difference in blood glucose level between the two groups before treatment (P> 0.05). After the treatment, the blood sugar control of pregnant women in the observation group was significantly better than that of the control group (P <0.05). The blood glucose control rate in the observation group was 91.67% (46.67%, P <0.05). Pregnancy complications, neonatal hypoglycemia and neonatal jaundice in observation group were significantly lower than those in control group (all P <0.05). Conclusions Metformin combined with insulin in the treatment of gestational diabetes mellitus can effectively improve various indexes of blood glucose, meanwhile, it can also improve the outcome of pregnancy and is worthy of clinical application.