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为获得较高滴度的甲型肝炎病毒抗原（以下简称HAAg），除有优良的毒种外，选择最佳收获期是关键。本文观察了HAV在细胞内的增殖动态，以确定病毒滴度达到高峰的最佳收获期。这对制备甲肝疫苗及甲肝诊断制剂均有实用价值。实验用已适应KMB17人胚肺二倍体细胞的甲肝病毒H。减毒株
In order to obtain a higher titer of hepatitis A virus antigen (hereinafter referred to as HAAg), in addition to having excellent virulence, the choice of the best harvest is the key. In this paper, we observed the intracellular proliferative activity of HAV to determine the optimal harvest period for peak virus titer. This preparation of hepatitis A vaccine and hepatitis A diagnostic preparations have practical value. Experimental Hepatitis A virus H that has been adapted to KMB17 human embryo lung diploid cells. Attenuated strains