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多种药物在唾液中排泄已成为近几年一些研究中的课题。因为研究表明,唾液中的药物浓度与血浆中的药物浓度几乎相平行,所以在药物治疗监视或药物代谢动力学研究中可以用唾液代替血浆。用唾液有许多方便之处,取材容易,患者自己就能收集。现已证明,异烟肼存在各种体液中。唾液样本中的异烟肼在冰冻条件下不稳定,保持贮存稳定的确切温度还不清楚。已知血浆样本中的异烟肼在—70℃条件下才完全稳定。因此,本文主要检测在几种不同温度和时间下异烟肼和乙酰异烟肼在唾液中的稳定性,同时也检测了叠氮
The excretion of many drugs in saliva has become a research topic in recent years. Because research shows that the concentration of drug in saliva is nearly parallel to the concentration of drug in plasma, saliva can be used instead of plasma in drug therapy monitoring or pharmacokinetic studies. There are many convenient saliva, easy to draw, the patient can collect. It has been shown that isoniazid exists in various body fluids. Isoniazid in the saliva sample is not stable under freezing conditions and it is unclear whether the exact temperature at which storage is stable. It is known that isoniazid in plasma samples is completely stable at -70 ° C. Therefore, this paper mainly tests the stability of isoniazid and isoniazid in saliva at several different temperatures and times, and also tests the azide