论文部分内容阅读
采用流式细胞术观察生长抑素衍生物SMS 201-995对BALB/c小鼠结肠腺癌(CT26)肝脏转移瘤生长的抑制作用。结果表明:与对照组相比,SMS 201-995治疗组小鼠肝脏转移瘤中肿瘤细胞增殖指数和S期细胞百分比明显降低(P<0.01),而GO/G1期细胞百分比则明显增加。同时,治疗组肝脏表面肿瘤结节数量明显减少,体重减轻延缓;生存期延长,因此,SMS 201-995对抑制结肠癌肝脏转移性肿瘤的生长具有一定的作用。
Flow cytometry was used to observe the inhibitory effect of somatostatin derivative SMS 201-995 on the growth of liver metastases of colon adenocarcinoma (CT26) in BALB/c mice. The results showed that compared with the control group, the tumor cell proliferation index and the percentage of S phase cells in the metastatic tumors of the SMS 201-995 treatment group were significantly lower (P<0.01), while the percentage of cells in the GO/G1 phase was significantly increased. At the same time, the number of tumor nodules on the surface of liver in the treatment group was significantly reduced, weight loss was delayed, and the survival period was prolonged. Therefore, SMS 201-995 has a certain effect on inhibiting the growth of liver metastatic tumors of colon cancer.