THAT the bacteriophages can display human antibody fragments on their surfaces equivalent tothe mammalian immune repertoire provides a new and powerful means of making human anti-bodies for immunotherapy. This technique combines production, selection and affinity matura-tion in numerous imaginative ways. The phage antibody display systems have an advantageover the conventional hybridoma technique in the generation of human antibody and the development of an affinity maturation process that mimics the immune system. Since the first phage THAT the bacteriophages can display human antibody fragments on their surfaces equivalent to mammalian immune repertoire provide a new and powerful means of making human anti-bodies for immunotherapy. This technique combines production and selection and affinity matura- tion in numerous imaginative ways. The phage antibody display systems have an advantage over the conventional hybridoma technique in the generation of human antibody and the development of an affinity maturation process that mimics the immune system. Since the first phage