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乳糜泻(Celiac sprue)或非热带性口炎性腹泻是吸收不良综合症的一种,是以体重减轻、腹部肿胀、腹泻、脂肪痢及吸收功能异常为特征的遗传性疾病。患病者往往小肠结构异常,绒毛倒状和表面上皮发生变化,不能耐受小麦或其制品中的面筋(Gluten)。目前认为,面筋蛋白质通过两种机制引起吸收不良及组织结构改变。中毒机制认为,病人缺乏一种通常能将面筋水解成小肽和氨基酸的特异粘膜肽酶,由于毒性产物蓄积而导致脂肪痢和肠上皮脱落。免疫学机制则认为,HLA 型抗原量增加的易感性病人不能耐受食
Celiac sprue or non-tropical stomatitis is a form of malabsorptive syndrome that is a genetic disorder characterized by weight loss, abdominal swelling, diarrhea, steatorrhea and dysfunctional absorption. Sick patients are often abnormal intestinal structure, inverted hair down and the surface epithelial changes, can not tolerate gluten in wheat or its products (Gluten). It is currently believed that gluten proteins cause malabsorption and structural changes through two mechanisms. The poisoning mechanism suggests that the patient lacks a specific mucosal peptidase that typically hydrolyzes gluten to small peptides and amino acids, causing steatorrhea and intestinal epithelial shedding due to accumulation of toxic products. Immunological mechanism is that the increased susceptibility of HLA-type antigen patients can not tolerate eating