口服一定剂量阿斯匹林和潘生丁时,可对非洲猕猴由胶原激活的血小板聚集效应产生影响:当低浓度胶原时聚集效应受到抑制,高浓度时则不被抑制。但血小板释出5-羟色胺的数量则因用药而明显减少:血小板环加氧酶活性受到抑制:而血栓素合成酶、脂质加氧酶和主动脉前列腺环素样活性均未受到影响。 Oral doses of aspirin and dipyridamole affect collagen-activated platelet aggregation in African macaques: aggregation is inhibited at low concentrations of collagen and is not inhibited at high concentrations. However, the amount of serotonin released from platelets was significantly reduced due to the administration of drugs: platelet cyclooxygenase activity was inhibited: thromboxane synthase, lipoxygenase and aortic prostacyclin-like activity were not affected.