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人体内的血液成分及造血器官对各种药物的作用较为敏感,所以临床上常常能见到各种药物性血液病的发生。 再生障碍性贫血 氯霉素是导致此病的代表药物。主要有两个原因:一是大剂量给药引起,此是可逆的,死亡率低;二是人体的特异反应,与剂量无关,虽然发生率低,但死亡率高。另外还有巯嘌呤、苯丙氨基氮芥、长春新碱、白消安、医用砷剂、秋水仙碱、卡比马唑、氯磺丙脲、三甲双酮等,亦可导致再障。
Human blood components and hematopoietic organs on the role of various drugs are more sensitive, so clinically often see a variety of drug-induced blood disease. Aplastic anemia Chloramphenicol is the leading cause of the disease. There are two main reasons: one is caused by high-dose administration, which is reversible and the mortality rate is low. Second, the specific response of the human body has nothing to do with the dose. Although the incidence is low, the mortality rate is high. There are also mercaptopurine, phenylpropylamino nitrogen mustard, vincristine, busulfan, medical arsenic, colchicine, carbamazepril, chlorpropamide, trimethadione, etc., can also lead to aplastic anemia.