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采用微量细胞病变抑制法测定136例中枢神经系统病毒感染患者急性期与恢复期血液和脑脊液干扰素。结果急性期血液与脑脊液中分别有106例(77.9%)和97例(71.3%)测出干扰素活性,平均滴度为10.5IU/ml 和13.9IU/ml。急性期干扰素测出阳性率和滴度明显高于恢复期阳性率和滴度,且脑脊液干扰素滴度高于血液干扰素滴度(P<0.05)。不同病原感染机体干扰素阳性率和滴度存在差异。提示中枢神经系统疾病感染机体可产生干扰素,并在早期抵抗病毒感染中起重要作用。
136 cases of central nervous system virus infection in patients with acute and convalescent blood and cerebrospinal fluid interferon determination. RESULTS: Interferon activity was detected in 106 (77.9%) and 97 (71.3%) patients in the acute phase of blood and cerebrospinal fluid with mean titers of 10.5 IU / ml and 13.9 IU / ml, respectively. The positive rate and titers of interferon in acute phase were significantly higher than those in recovery phase, and the titers of interferon in cerebrospinal fluid were higher than those of interferon in serum (P <0.05). Different pathogens infected with interferon positive rate and the titer difference. Tip Central nervous system infection can produce interferon in the body, and plays an important role in early resistance to viral infection.