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本文应用高效液相色谱法对615小鼠静注高三尖杉酯碱多相脂质体(139-5号)后的体内药物分布进行了探讨。结果显示139-5号给药后在肠、脾、骨髓中含量较高;与该药水溶液相比,高三尖杉酯碱(HH)在脾、骨髓、肾中含量较高,而在心、肝中含量较低。
In this paper, high performance liquid chromatography (HPLC) was used to investigate the in vivo drug distribution of 615 homoharringlline polyphasic liposomes (No. 139-5). The results showed that the content of HH in the intestine, spleen and bone marrow was higher than that of the drug solution. Compared with the aqueous solution, homoharringtonine (HH) had a higher content in the spleen, bone marrow and kidney, In the lower content.