小鼠感染浙江杭州、江苏无锡、安徽贵池、江西南昌、湖北汉阳、湖南岳阳和云南大理等7个地区日本血吸虫后32～35d,分别单次ig吡喹酮400mg/kg治疗。结果发现云南大理地区血吸虫感染组的疗效最差,而其他6个地区血吸虫感染组间的疗效无明显差别。认为云南大理地区血吸虫对吡喹酮的敏感性低于安徽等6个地区血吸虫。 The mice were infected with Schistosoma japonicum in 7 districts of Hangzhou, Zhejiang Province, Jiangsu Wuxi, Guichi of Anhui, Nanchang of Jiangxi, Hanyang of Hubei, Yueyang of Hunan and Dali of Yunnan for 32-35 days after treatment with 400 mg / kg of praziquantel. The results showed that the efficacy of schistosomiasis infection group in Dali, Yunnan Province, the worst, while the other six areas of schistosomiasis infection between groups no significant difference. It is considered that the sensitivity of schistosoma to praziquantel in Dali, Yunnan Province is lower than that of schistosome in 6 areas, such as Anhui.