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甲壳质(chitin)是一类自然界广泛存在的可再生资源,主要从甲壳动物的甲壳中提取。甲壳质于1811年被发现,1950年以来进行了广泛应用研究,其在药剂中应用是目前甲壳质研究的一个热点。甲壳质化学名为聚N-乙酰-D-葡萄糖胺,脱乙酰后成壳聚糖(chitosan)。它们具有无毒、难溶、成纤维、成胶、络合、酶解等优良性质。最令人注目的是用于控释、缓释药物及其它生物活性物质。一、甲壳质用作直接压片助剂甲壳质及壳聚糖直接压片研究表明,
Chitin is a type of renewable resource widely found in nature, extracted mainly from the crustacean carapace. Chitin was discovered in 1811, and has been widely used since 1950. Its application in pharmaceutics is a hot spot in chitin research. Chitin chemistry called poly-N-acetyl-D-glucosamine, after deacetylation into chitosan (chitosan). They are non-toxic, insoluble, into fiber, plastic, complex, enzymatic hydrolysis and other fine properties. The most notable is for controlled release, sustained release drugs and other bioactive substances. First, the use of chitin as a direct compression aid Chitin and chitosan direct compression studies have shown that,