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早在1929年就有人提到钴可致多红血球症,但自1948 Rickes 和 Smith 分别自肝中析出维生素 B_(12)的结晶并得知其中含有4%的钴(1)以后,钴的生理作用才逐渐被人重视。近来在畜牧业和临床上这个问题也开始被注意了,如反刍类饲料缺钴则食欲减退(2、4)、体重减轻、发生恶性贫血、衰弱以至死亡(4);又如用钴盐可治疗贫血症,但患者有时出现中毒现象如食欲减退、恶心、呕
As early as 1929, some people mentioned that cobalt can cause multiple erythropoiesis, but since 1948 Rickes and Smith respectively precipitated the crystals of vitamin B 12 from the liver and learned that 4% of them contained cobalt (1), the physiology of cobalt The role is gradually being taken seriously. Recently, this issue has also begun to be noticed in animal husbandry and in clinical practice. For example, the lack of cobalt in ruminant feeds reduces appetite (2, 4), weight loss, occurrence of pernicious anemia, debilitation, and death (4); Treatment of anemia, but patients sometimes suffer from poisoning such as loss of appetite, nausea, and vomiting