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本研究发现当鼠腹腔巨噬细胞或牛主动脉平滑肌细胞经单核细胞集落刺激因子(M—CSF)预孵育后再加入轻度修饰LDL(mm—LDlL)可显著增加两种细胞内胆固醇酯蓄积程度。这说明在致细胞内脂质蓄积方面mm—LDL与M—CSF具有协同作用。还发现M—CSF有加强巨噬细胞氧化修饰正常LDL的作用,这可能是其作用机制之一。
This study found that when mouse peritoneal macrophages or bovine aortic smooth muscle cells pre-incubated with monocyte colony-stimulating factor (M-CSF) and then mildly modified LDL (mm-LDL) can significantly increase both intracellular cholesterol esters Accumulation level. This suggests that the combination of mm-LDL and M-CSF has a synergistic effect on intracellular lipid accumulation. M-CSF was also found to enhance macrophage oxidative modification of normal LDL, which may be one of the mechanisms of action.