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变态反应性疾患特别是Ⅰ型变态反应性疾患,是在肥大细胞和嗜碱性细胞释放出来的组胺(Hi)、白细胞三烯(LT)、血小板活性因子(PAF)等化学介质的参与下发生的。所以作为变态反应性疾患的治疗药是用于阻碍这些化学介质释放(狭义的抗变态反应药)和拮抗这些化学介质的药物。一、Hi的释放及其抑制1.Hi的释放Hi是在肥大细胞的贮存颗粒中,在由蛋白和肝素组成的基质中,进行离子结合形成的复合物。Hi的释
Allergic disorders, particularly type I allergic disorders, are involved in the release of histamine (Hi), leukotriene (LT), and platelet-activating factor (PAF) from mast cells and basophils occurring. So therapies that are used as an allergic disorder are drugs that block the release of these chemical mediators (narrower anti-allergic agents) and antagonize these chemical mediators. First, the release of Hi and its inhibition 1. Release of Hi Hi is a compound formed by ion-binding in mast cell storage granules in a matrix composed of protein and heparin. Hi’s release