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目的通过青少年骨肉瘤规范化治疗前后体内总碱性磷酸酶(TALP)和骨型碱性磷酸酶(BALP)变化,评估患者治疗效果、复发或转移风险。方法选取2007年1月-2015年6月患者120例,分为骨肉瘤组、骨折组,另选取60例本院健康体检者为对照组,每组60例。检测各组TALP和BALP含量。结果病程2周骨肉瘤组、骨折组血清TALP、BALP水平明显高于对照组,差异有统计学意义(P<0.05)。骨折组发病6周、8周后TALP、BALP水平呈下降趋势。骨肉瘤组肿瘤切除、化疗药物敏感、无远处转移患者TALP、BALP水平持续下降,术后3个月与对照组比较差异有统计学意义(P<0.05)。化疗效果差、术后局部复发、早期出现转移的骨肉瘤患者TALP、BALP水平高于对照组,差异有统计学意义(P<0.05)。结论检测青少年骨肉瘤患者体内TALP、BALP变化,对手术前后化疗效果评估、肿瘤复发、转移风险预测有重要意义。
Objective To assess the effect of treatment, recurrence or metastasis in patients with osteosarcoma by standardized changes of total alkaline phosphatase (TALP) and bone alkaline phosphatase (BALP) before and after treatment. Methods From January 2007 to June 2015, 120 patients were divided into osteosarcoma group and fracture group. Another 60 healthy subjects in our hospital were selected as the control group, 60 cases in each group. The contents of TALP and BALP in each group were detected. Results The serum levels of TALP and BALP in the two-week osteosarcoma and fracture groups were significantly higher than those in the control group (P <0.05). Fracture group onset of 6 weeks, 8 weeks after TALP, BALP levels showed a downward trend. TALP and BALP levels in patients with osteosarcoma were significantly lower than those in the control group (P <0.05) after tumor resection, chemosensitivity and distant metastasis. TALP and BALP levels in patients with early-stage osteosarcoma were higher than those in control group, with significant difference (P <0.05). Conclusion Detection of TALP and BALP in patients with adolescent osteosarcoma is of great significance in the evaluation of the effect of chemotherapy before and after surgery, tumor recurrence and metastasis risk prediction.