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本实验用６－羟基多巴胺损毁鼠前脑去甲肾上腺素（Ｎｏｒｅｐｉｎｅｐｈｒｉｎｅ；ＮＥ）能神经后，将富含ＮＥ的鼠胎蓝斑区细胞悬液植入单或双侧杏仁核－梨状区皮质，予慢性电刺激海马制成癫痫模型。经行为和电生理研究发现移植物对点燃癫痫的发生和发展及海马细胞的痫样放电具有明显的阻抑作用，且双侧靶点内移植的抑制作用明显高于单侧移植。用络氨酸羟化酶的特异抗血清对前脑切片进行免疫细胞化学染色光镜分析，发现移植的ＮＥ能神经元存活、生长良好，并发出纤维支配海马。用高效液相色谱－电化学检测法测定移植靶点周围脑组织的单胺类神经递质含量，发现接受蓝斑移植的动物端脑内ＮＥ含量明显增高，其中以接受双侧靶点内移植的动物增高更为显著。经统计分析发现前脑ＮＥ含量的高低与癫痫的点燃速度呈负相关，而蓝斑移植物对点燃癫痫的阻抑作用是通过移植的ＮＥ能神经元在宿主动物脑内存活并生产和提高脑内ＮＥ含量来实现的。
In this experiment, 6-hydroxydopamine destroyed the norepinephrine (NE) nerves in the forebrain forebrain and then implanted NE-rich mouse motoneurophil cell suspension into the single or bilateral amygdala-cortex , To chronic electrical stimulation of the hippocampus made epilepsy model. The behavioral and electrophysiological studies found that the graft had a significant inhibitory effect on the occurrence and development of ignition epilepsy and epileptiform discharge in hippocampal cells, and the inhibitory effect of transplantation in bilateral target was significantly higher than that in unilateral transplantation. Immunocytochemical staining of forebrain sections by specific antiserum of tyrosine hydroxylase revealed that the transplanted NE neurons survived and grew well and distributed fiber-dominated hippocampus. The contents of monoamine neurotransmitters in the brain tissue around the transplanted target were measured by HPLC-electrochemical detection. It was found that NE content in the brain of the rats subjected to the BLA was significantly increased, The animals increased more significantly. The statistical analysis showed that the content of NE in the forebrain was negatively correlated with the ignition speed of epilepsy, while the inhibitory effect of LGP on the ignition of epilepsy was via the transplanted NE neurons surviving in the host animal brain and producing and improving the brain NE content to achieve.