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目的 探讨广州管圆线虫性肺炎的病理变化特征。方法 大白鼠感染管圆线虫后 ,用组织学、组织化学及电镜观察肺组织的形态改变。结果 成虫寄生于肺动脉内形成虫栓 ,虫卵及幼虫阻塞肺毛细血管形成异物肉芽肿结节。肺血管内弹力膜断裂 ,坏变性小动脉炎及内皮细胞呈弥漫性或簇状乳头状增生。肺部还可伴随支气管炎 ,肺炎及肺脓肿等改变。结论 实验性广州管圆线虫性肺炎的主要病变为成虫和虫卵的栓塞血管 ,血管的坏变和内皮细胞高度增生 ,成虫的栓塞 ,广泛的虫卵结节及伴发严重的肺脓肿是造成死亡的主要因素。
Objective To investigate the pathological changes of C. elegans pneumonia in Guangzhou. Methods After infection of C. elegans, the morphological changes of lung tissue were observed by histology, histochemistry and electron microscopy. Results Adult parasites in the pulmonary artery formation of thrombus, eggs and larvae blocked pulmonary capillaries foreign body granuloma nodules. Pulmonary vascular membrane rupture, degenerative arteritis and endothelial cells were diffuse or clustered papillary hyperplasia. The lungs may also be accompanied by bronchitis, pneumonia and lung abscess and other changes. Conclusions The main pathological changes of experimental angiostrongyliasis pneumoniae are the embolized vessels of adult and ovum, the degeneration of blood vessels and the hyperplasia of endothelial cells. The embolization of adults, extensive egg nodules and severe pulmonary abscess result The main factor of death.