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目的：了解白细胞介素－１受体拮抗剂（ＩＬ－１ｒａ）基因多态性在中国正常人群中的分布及其与不同种族比较的特点。方法：用ＰＣＲ方法对９８名正常人群ＩＬ－１ｒａ基因ＶＮＴＲ多态性进行了观察，并结合文献进行了不同种族间的分析比较。结果：中国正常人群以ＩＬ１ＲＮ＊１等位基因发生频率最高，ＩＬ１ＲＮ＊２等位基因次之，与英国白种人相比，中国人ＩＬ１ＲＮ＊１等位基因的发生频率明显高于英国人，而英国人ＬＩ１ＲＮ＊２等位基因的发生频率明显高于中国人。结论：ＩＬ－１ｒａ基因ＶＮＴＲ基因多态性在不同种族间的分布存在着明显的差异，这种差异有可能是导致一些疾病在不同种族间的发病率和临床表现上存在显著不同的因素之一。
Objective: To understand the distribution of interleukin-1 receptor antagonist (IL-1ra) gene polymorphism in Chinese normal population and its comparison with different races. Methods: The VNTR polymorphism of IL-1ra gene in 98 normal subjects was observed by PCR and analyzed and compared among different races based on the literature. Results: The frequency of IL1RN * 1 allele in Chinese normal population was the highest, followed by IL1RN * 2 allele. Compared with British white people, the frequency of IL1RN * 1 allele in Chinese was significantly higher than that in British. The British LI1RN * 2 allele frequency was significantly higher than the Chinese. CONCLUSIONS: The VNTR gene polymorphism of IL-1ra gene is significantly different among different races and may be one of the factors that lead to significant differences in the morbidity and clinical manifestations of some diseases among different races .