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本研究观察GSH与化疗药合用对DEN大鼠肝癌模型的作用。DEN灌胃8mg／kg／d诱发大鼠肝癌模型。GSH预防性给药合用Adr治疗无一大鼠出现肿瘤，ChH＋Adr治疗给药大鼠肝癌发生率为12．5％（p＜0．01），Cisp和Taxol不论单用或与CSh治疗性合用大鼠肝癌发生率与DEN对照组无明显差异（P＞0．05），但3种化疗药与CSH合用模型鼠的死亡率降低。DEN诱发肝癌形成和化疗药的毒性反应均与自由基生成有关，GSH预防DEN致癌作用及降低化疗药毒性则基于它的抗氧化作用。
This study was to observe the effect of GSH combined with chemotherapeutic agents on liver cancer model in DEN rats. DEN gavage 8mg / kg / d induced rat liver cancer model. None of the rats in the prophylactic administration of GSH combined with Adr developed tumors. The incidence of hepatocellular carcinoma was 12.5% (p <0.01) in rats treated with ChH + Adr, and both Cisp and Taxol, either alone or in combination with CSh, There was no significant difference in the incidence of hepatocellular carcinoma between HCC and DEN control group (P> 0.05), but the mortality rate of three chemotherapy drugs and CSH combined model mice decreased. DEN-induced hepatocarcinogenesis and chemotherapeutic drug toxicity are related to free radical generation, GSH to prevent carcinogenesis of DEN and reduce the toxicity of chemotherapy is based on its antioxidant effect.