Under the combined influences of special topography and the long term mining in Nanfen Open Pit Iron Mine, many large scale landslide masses appeared in heading side of stope, and tens of millions of iron mine is buried underside, making great economic losses. In order to guide the safety mining and increase the supply quantity, this paper through the use of MSARMA-method and the ’’MSARMA evaluation and analytical system for slope stability analysis’’ based on this method, which aimed at the quantitative evaluating of the slope stability before and after the actual mining below the slip mass, and the sensitivity analysis for the main influencing factor, providing scientific proof for the parameter optimization of open mine surface slope, the security and sustainable exploitation. Under the combined influences of special topography and the long term mining in Nanfen Open Pit Iron Mine, many large scale landslide groups Have in heading side of stope, and tens of millions of iron mine is buried underside, making great economic losses. In order to guide the safety mining and increase the supply quantity, this paper through the use of MSARMA-method and the ’MSARMA evaluation and analytical system for slope stability analysis’’ based on this method, which aimed at the quantitative evaluating of the slope stability before and after the actual mining below the slip mass, and the sensitivity analysis for the main influencing factor, providing to scientific proof for the parameter optimization of open mine surface slope, the security and sustainable exploitation.