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将４０例病人随机分为压中定组（ｎ＝２０），对照组（ｎ＝２０）。以０．５ｍｇ·ｋｇ－１压宁定诱导插管，观察诱导即刻、１ｍｉｎ、３ｍｉｎ和插管时，插管后１ｍｉｎ、５ｍｉｎ时两组病人的收缩压（ＳＢＰ）、舒张压（ＤＢＰ）、心率（ＨＲ）变化。结果表明：压宁定组的ＳＢＰ、ＤＢＰ在插管时低于对照组（Ｐ＜０．０５）；ＨＲ在插管前后无差异（Ｐ＞０．０５），对照组ＨＲ在插管后明显上升，差异显著（Ｐ＜０．０５）。插管后５ｍｉｎ两组ＳＢＰ、ＤＢＰ及ＨＲ无差异（Ｐ＞０．０５）。表明压宁定可以预防气管插管时的心血管反应。
Forty patients were randomized to receive nocturopsin (n = 20) and control (n = 20). The rats were intubated with 0.5 mg · kg-1 nifedipine for 24 hours. The systolic blood pressure (SBP), diastolic blood pressure (DBP), and diastolic blood pressure Heart rate (HR) changes. The results showed that SBP and DBP were lower in the ningling group than those in the control group (P <0.05); HR was not significantly different before and after intubation (P> 0.05); HR in the control group was significantly higher after intubation Increased significantly (P <0.05). After intubation 5min SBP, DBP and HR no difference between the two groups (P> 0.05). Showed that nifedipine can prevent cardiovascular response when tracheal intubation.