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目的探讨在辅助生殖技术中,Y染色体长度异常对精液各项指标影响。受精、胚胎卵裂情况及妊娠结局的影响。方法对2009年4月至2009年10月在我院生殖中心进行体外受精/卵胞浆内单精子注射-胚胎移植(IVF/ICSI-ET)助孕的128例患者(共136个周期治疗)进行前瞻性研究,大Y染色体组共4个治疗周期(3例患者),小Y染色体组共3个鲜胚移植周期,1个冻胚移植周期。结果 (1)Y染色体长度异常患者组精液形态正常值8-21(17.02±4.24),低于正常标准;(2)大Y组临床妊娠率为0(0/4%);(3)小Y组不孕年限2-4年(3.22±0.83),获卵数7-23枚(17.19±6.17),受精率42.9%和卵裂率60%,临床妊娠率为25%(1/4)。结论 Y染色体长度异常影响精液的畸形率;对卵子受精率、胚胎卵裂率及发育潜能有一定的影响。
Objective To explore the effect of abnormal Y chromosome length on various indexes of semen in assisted reproductive technology. Fertilization, embryo cleavage and pregnancy outcome. Methods A total of 128 patients with IVF / ICSI-ET assisted pregnancy (total of 136 cycles) from April 2009 to October 2009 in the Reproductive Center of our hospital were enrolled in this study. Prospective study, large Y chromosome group a total of 4 treatment cycles (3 patients), a small Y chromosome group a total of three fresh embryo transfer cycle, a frozen embryo transfer cycle. Results (1) The normal sperm morphology of patients with abnormal Y chromosome length was 8-21 (17.02 ± 4.24), which was lower than the normal standard. (2) The clinical pregnancy rate was 0 (0/4%) in the large Y group. (3) Y group was 2-4 years old (3.22 ± 0.83), with 7-23 eggs (17.19 ± 6.17), fertilization rate 42.9% and cleavage rate 60%, clinical pregnancy rate was 25% (1/4) . Conclusion Abnormal length of Y chromosome affects the deformity rate of semen; it has certain influence on fertilization rate, cleavage rate and developmental potential of embryos.