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目的探讨超敏C反应蛋白(hs-CRP)和心肌酶的检测在新生儿窒息后心肌损伤中的诊断价值。方法将入选新生儿分为二组,对照组31例,窒息组75例(轻度窒息46例,重度窒息29例),分别测定两组新生儿出生后24h内和第8天的血hs-CRP和心肌酶,并比较分析。结果轻度和重度窒息新生儿血清hs-CRP和心肌酶水平显著高于对照组(P<0.05和P<0.01),重度窒息组血hs-CRP和心肌酶水平高于轻度窒息组(P<0.05),治疗后窒息组hs-CRP和心肌酶水平明显下降,但重度组仍略高于轻度组,差异无显著性(P>0.05)。结论新生儿窒息缺氧可导致心肌损伤,血清hs-CRP和心肌酶检测可作为判断心肌损伤及严重程度的指标。
Objective To investigate the diagnostic value of hs-CRP and myocardial enzyme in myocardial injury after neonatal asphyxia. Methods The newborn infants were divided into two groups: control group (31 cases), asphyxia group (75 cases), mild asphyxia (46 cases) and severe asphyxia (29 cases). The levels of hs- CRP and myocardial enzymes, and comparative analysis. Results Serum levels of hs-CRP and myocardial enzymes in mild and severe asphyxia neonates were significantly higher than those in control group (P <0.05 and P <0.01), while levels of serum hs-CRP and myocardial enzymes in severe asphyxia group were higher than those in mild asphyxia group <0.05). The levels of hs-CRP and myocardial enzymes in asphyxia group were significantly lower than those in mild group after treatment, but the difference was not significant (P> 0.05). Conclusions Neonatal asphyxia and hypoxia can lead to myocardial injury. The detection of serum hs-CRP and myocardial enzymes can be used as an indicator of myocardial injury and severity.