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本文利用低压舱内模拟３０００、５０００、８０００和１００００ｍ高度缺氧条件下，观察大鼠急性缺氧脑组织中腺苷三磷酸酶（ＡＴＰａｓｅ）组织化学的改变，并应用图像分析技术进行了定量分析。结果显示，在顶叶皮层，各组随高度增加ＡＴＰａｓｅ呈逐渐下降趋势；在海马，３０００ｍ活性轻度升高，５０００～１０００ｍ逐渐降低；在小脑，５０００ｍ时有一过性轻度上抬现象。１００００ｍ高度时，各脑区的ＡＴＰａｓｅ活性均显著下降，与对照组及８０００ｍ以下各组均有显著差异（Ｐ＜００１）。大脑较之小脑更敏感。脑组织的ＡＴＰａｓｅ活性变化影响了脑的生理功能与病理改变。
In this study, the changes of histochemistry of ATPase in acute hypoxic rat brain were observed under hypoxia conditions at 3000, 5000, 8000 and 10000m in a low-pressure cabin. Quantitative analysis was performed using image analysis technique . The results showed that in the parietal cortex, ATPase showed a gradual downward trend with increasing height in each group. In the hippocampus, the activity of 3000m increased slightly and decreased gradually from 5000m to 1000m. In the cerebellum, there was a transient mild elevation phenomenon at 5000m. At the height of 10000m, the ATPase activity in each brain region decreased significantly, which was significantly different from the control group and the group below 8000m (P <001). The brain is more sensitive than the cerebellum. Changes in brain ATPase activity affect the physiological function of the brain and pathological changes.