论文部分内容阅读
目的探讨血清IL-8和IL-13水平在新生儿细菌感染的早期诊断和临床转归中意义。方法用ELISA测定三组血清细胞因子的水平。感染组:21例细菌感染新生儿(治疗前和有效治疗后);非感染组:20例非感染性疾病新生儿;脐血组:30例正常新生儿。结果感染组IL-8和IL-13水平较非感染组升高(P<0.05);感染组治疗后IL-8水平较治疗前下降。结论新生儿细菌感染时血清IL-8和IL-13显著升高,可作为新生儿细菌感染的早期诊断指标,IL-8可用来评价疗效。
Objective To investigate the significance of serum IL-8 and IL-13 levels in the early diagnosis and clinical outcome of neonatal bacterial infection. Methods Serum levels of cytokines were measured by ELISA in three groups. Infection group: 21 cases of bacterial infection in newborns (before treatment and after effective treatment); non-infected group: 20 cases of non-infectious disease neonates; cord blood group: 30 normal newborns. Results The levels of IL-8 and IL-13 in the infected group were significantly higher than those in the non-infected group (P <0.05). The IL-8 level in the infected group was lower than that before treatment. Conclusions Serum IL-8 and IL-13 levels are significantly increased in newborns with bacterial infection, which can be used as an early diagnostic indicator of neonatal bacterial infection. IL-8 can be used to evaluate the efficacy.