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目的:探讨三七总皂苷对肝损伤小鼠的保护作用。方法:采用昆明种小鼠,随机分为正常组、模型组、PNS高、中、低剂量组(400、200、100mg/kg)、联苯双脂组(150mg/kg)。BCG2.5mg iv致敏小鼠,第十天给予LPS7.5μg攻击复制免疫性肝损伤模型,连续给药十天。采用分光光度法对各组小鼠血清中的ALT、AST含量进行测定。结果:PNS可以显著降低肝损伤小鼠的脾脏、肝脏指数,并显著降低肝损伤小鼠血清ALT、AST含量(P<0.05)。结论:PNS对免疫性肝损伤小鼠具有一定的保护作用。
Objective: To investigate the protective effect of Panax notoginseng saponins on liver injury in mice. Methods: Kunming mice were randomly divided into normal group, model group, high, medium and low dose PNS groups (400,200,100mg / kg) and biphenolipid group (150mg / kg). BCG 2.5mg iv sensitized mice, on the tenth day LPS7.5μg challenge replication immune liver injury model, continuous administration of ten days. The serum ALT and AST levels in each group of mice were determined by spectrophotometry. Results: PNS could significantly reduce the spleen and liver index of liver injury mice, and significantly reduce the serum ALT and AST levels in liver injury mice (P <0.05). Conclusion: PNS has protective effect on mice with immunological liver injury.