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轻度认知障碍(mild cognitive impairment,MCI)是介于正常衰老和痴呆之间的一种认知损伤状态,由于阿尔兹海默症(alzheimer’s disease,AD)等认知障碍疾病具有不可逆转性,因此对老年人群中MCI患者的早期干预治疗意义重大。而研究表明血清总胆固醇水平升高是AD的高危因素,因此,本文综述了国内外关于高胆固醇血症与MCI关系的研究进展,提示及时采取措施控制血清胆固醇水平对早期预防MCI并干预MCI向AD转化具有重要意义。
Mild cognitive impairment (MCI) is a cognitive impairment between normal aging and dementia. Since cognitive impairment disorders such as Alzheimer’s disease (AD) are irreversible , So early treatment of MCI patients in the elderly population is of great significance. However, studies have shown that elevated serum total cholesterol is a high risk factor for AD. Therefore, this review summarizes the research progress on the relationship between hypercholesterolemia and MCI both at home and abroad, suggesting that prompt measures to control serum cholesterol levels should be used to prevent MCI and prevent MCI AD conversion is of great significance.