1,2,3,4,4a,5-六氢-10-H-二苯骈[a,d]环庚三烯-10-酮是全合成美丽红豆杉素A和B的模型化合物。我们设计了两条不同的合成路线,一是以环己酮为起始原料,在其α位引入苄基,然后进行Wittig-Horner反应,另一条路线是以(Ⅴ)为原料进行Reformatsky反应,最后都用PPA进行环合,均能制得[6+7+6]环型化合物Ⅲ。 1,2,3,4,4a, 5-hexahydro-10-H-dibenzo [a, d] cycloheptatrien-10-one is a model compound for the total synthesis of the beautiful taxol A and B. We have designed two different synthetic routes. One is cyclohexanone as the starting material, the benzyl group is introduced into the α position, and then the Wittig-Horner reaction is carried out. The other route is Reformatsky reaction with (V) Finally, PPA was used for cyclization, both of which could produce [6 + 7 + 6] cyclic compounds III.