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人类脑肿瘤研究证实,变异的致癌前体不仅能决定神经干细胞特性还能引发脑肿瘤。研究报道骨形成蛋白(bone morphogenetic proteins,BMPs)中的骨形成蛋白4(BMP4)能在很大程度上减少人脑恶性胶质瘤(glioblastomas,GBMs)的干细胞样肿瘤起始细胞。移植的胶质瘤细胞在体外短暂性接触BMP4将失去其发展为脑GBMs的能力。更重要地是,在移植了人胶质
Studies in human brain tumors have confirmed that mutated oncogenic precursors not only determine the properties of neural stem cells but also brain tumors. It has been reported that BMP4 in bone morphogenetic proteins (BMPs) has been shown to significantly reduce stem cell-like tumor-initiating cells in human glioblastomas (GBMs). Transplanted glioma cells transiently exposed to BMP4 in vitro will lose their ability to develop into brain GBMs. More importantly, human glia are transplanted