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目的:探讨肠安Ⅰ号及含有低浓度肠安Ⅰ号成分的安慰剂对腹泻型肠易激综合征大鼠胸腺、脾脏指数的影响。方法:采用番泻叶灌胃+传统束缚应激刺激复制腹泻型IBS大鼠模型。中药用中药煎剂,得舒特溶液对照药物,治疗结束后,测定大鼠的胸腺、脾脏指数的含量。结果:肠安Ⅰ号高、中、低剂量组体重、胸腺、脾脏指数变化与模型组比较性差异有显著(P<0.05),其组间比较没有显著性意义;然而含5%、含10%肠安Ⅰ号组经过治疗,以上指标与模型组比较没有统计学意义(P>0.05)。结论:肠安Ⅰ号高、中、低剂量可通过增加大鼠的体重、胸腺、脾脏指数,提高大鼠的免疫功能,从而发挥对IBS的治疗作用;而含5%、含10%肠安Ⅰ号加辅料组没有药理作用,从而从中药的色、味方面模拟了肠安Ⅰ号的特点,起到了安慰剂对照作用。
Objective: To investigate the effects of Chang’an No.1 and placebo containing low concentration of Chang’an I on thymus and spleen index in rats with diarrhea-predominant irritable bowel syndrome. METHODS: The diarrhea-predominant IBS rat model was stimulated by senna lavage and traditional restraint stress. Traditional Chinese medicine decoction used for Chinese medicine and Deshuite solution control medicine. After treatment, the content of thymus and spleen index in rats was measured. Results: There were significant differences in body weight, thymus and spleen index between the high, middle and low doses of Chang’an I and the model group (P<0.05). There was no significant difference between the two groups; however, there was 5% and 10 The % bowel An group was treated. There was no statistically significant difference between the above indicators and the model group (P>0.05). Conclusion: The high, middle and low doses of Chang’an I can increase the immune function of rats by increasing the body weight, thymus and spleen index of rats, so as to exert therapeutic effects on IBS; 5% and 10% of enteral There was no pharmacological effect on the No. I plus excipients group, thus mimicking the characteristics of Chang’an I from the aspect of the color and taste of the Chinese medicine, which played a placebo-controlled effect.