烧伤病人麻醉时所需右旋筒箭毒(简称箭毒)的剂量比非烧伤病人约高3倍;需达到等同神经肌肉阻滞水平的血浆箭毒浓度约高5倍。但单纯用血浆蛋白结合箭毒的量增大,尚不能解释。有间接证据证明烧伤后神经肌肉接点发生变化,致使对箭毒反应不同。此外,箭毒经烧伤创面排渗量增多,肾小球滤过率增加药物随尿排出增多以及分布容积改变等都可能是箭毒用量需增大的原因,本文报道烧伤病人注用箭毒后药动学的变化和体内处置,并依此加以探讨。作者选择8例烧伤面积超过15%的病人,另选非烧伤外科病人6例作对照。两组病人的年龄、体 The dose of right-bellied poisonous arrow poison (referred to as arrow poison) required for the burn patients during anesthesia is about 3 times higher than that for non-burn patients; the plasma concentration of arrow poisoning, which is equivalent to the level of neuromuscular blockade, is about 5 times higher. However, the amount of plasma protein alone combined with arrowheads increased, still can not explain. There is indirect evidence that changes in neuromuscular junction after burn, resulting in different response to arrow poisoning. In addition, the arrowhead by the burn wound surface infiltration increased, increased glomerular filtration rate of drug excretion with the urine volume and distribution changes may be the need to increase the dose of arrowhead poisoning, this paper reports burn patients after injection with arrow poison Pharmacokinetic changes and in vivo disposal, and so on to be explored. The authors selected 8 patients with more than 15% burns and 6 non-burn patients as controls. Two groups of patients age, body