采用微生物法，对１６名男性健康志愿者单剂口服国产阿奇霉素胶囊后的药代动力学进行了研究。口服后不同时间收集血、尿标本。检测菌为藤黄八叠球菌２８００１。测定结果用３Ｐ８７软件经微机处理。结果：口服本品后药时曲线符合二室模型，主要药动学参数，峰时间为（１９６±０７８）ｈ，峰浓度为（１０２±０４０）ｍｇ／Ｌ，药时曲线下面积为（１６２６±３１９）ｍｇ·ｈ·Ｌ－１，消除半衰期为（４７４１±５３３）ｈ，１９２ｈ尿累积排出率为（１３１１±２２９）％。结果提示：国产阿奇霉素体内过程与进口阿奇霉素相仿 The microbiological method was used to study the pharmacokinetics of a single oral oral azithromycin capsule in 16 healthy volunteers. After oral administration of blood, urine samples at different times. The test strain is Sarcina lutea 28001. Measurement results using 3P87 software by the computer. Results: The drug-time curve of oral administration of this product accorded with two-compartment model. The main pharmacokinetic parameters were peak time (196 ± 078) h and peak concentration (102 ± 040) mg / L (1626 ± 319) mg · h · L-1, the elimination half-life was (4741 ± 533) h, and the accumulative discharge rate of urine at 192h was (1311 ± 2  29)%. The results suggest that: domestic azithromycin in vivo process and imported azithromycin similar