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目的 :了解嗜麦芽窄食单胞菌 (Sm)与新生儿呼吸机相关性肺炎 (NVAP)的关系。方法∶分析本院新生儿科近 3年来NVAP的呼吸道分泌物的细菌培养结果及临床资料。用VITEX AMS6 0做细菌鉴定及药敏分析 ,部分菌株采用K B法做药敏分析 ,均按美国临床实验室标准委员会 (NCCLS)最新版标准判断结果。结果∶Sm为NVAP第 2位主要病原菌 ,占总菌株的18.1%(15 / 83)。 15株Sm标本来自 14例患儿 ,SmNVAP占NVAP总例数的 2 2 .6 %(14/ 6 2 )。药敏结果显示Sm对替卡西林 克拉维酸耐药率最低 (0 ) ,其次是环丙沙星和头孢他啶 (均为 2 6 .7%) ,再次为阿米卡星 (4 0 %) ;对亚胺培南 西司他丁、庆大霉素、氨苄西林及头孢唑林全部耐药。结论∶Sm是本院NVAP的重要病原菌 ,且耐药率高 ,值得重视。
Objective: To understand the relationship between Stenotrophomonas maltophilia (Sm) and neonatal ventilator-associated pneumonia (NVAP). Methods: The bacterial culture results and clinical data of respiratory secretions from NVAP in our hospital during the past 3 years were analyzed. VITEX AMS6 0 was used for bacterial identification and drug susceptibility analysis. Some strains were susceptible to K B by drug susceptibility analysis. The results were judged according to the latest edition of the American Clinical Laboratory Standards Committee (NCCLS). Results: Sm was the second major pathogen of NVAP, accounting for 18.1% (15/83) of the total strains. Fifteen Sm samples were obtained from 14 patients, with SmNVAP accounting for 22.6% (14/62) of the total NVAP cases. Drug susceptibility results showed that Sm had the lowest rate of resistance to tacrolimus (0), followed by ciprofloxacin and ceftazidime (both 26.7%) and amikacin (40%) again. Imipenem cilastatin, gentamicin, ampicillin and cefazolin full resistance. Conclusion: Sm is an important pathogen of NVAP in our hospital and its resistance rate is high, so it deserves attention.