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目的 建立以WHO指南为基础的结核病细菌学耐药监测系统,掌握宁波市初始和获得性耐药水平。方法 采用整群抽样方法于1999年10月至2000年3月选择全市所有新发涂阳病例(包括复治涂阳病例),并对其全部培养阳性的菌株进行菌型鉴定及4种抗结核药物(INH、SM、RFP、EMB)的耐药测试。结果 总耐药率为22.44％,初始耐药率为17.87％,初始耐多药率为3.40％;获得性耐药率为78.95％,获得性耐多药率为42.11％。结论 宁波市结核病的初始耐药率处于较高水平,须进一步加强全市的结核病控制工作。
Objective To establish a tuberculosis bacteriological drug resistance surveillance system based on WHO guidelines and to grasp the initial and acquired drug resistance in Ningbo. Methods The cluster sampling method was used to select all newly smeared smear positive cases (including retreatment smear positive cases) from Oct. 1999 to Mar. 2000 in our city, and to identify all the strains with positive culture and four anti-TB Drug resistance test (INH, SM, RFP, EMB). Results The total drug resistance rate was 22.44%, the initial drug resistance rate was 17.87%, the initial multidrug resistance rate was 3.40%, the acquired drug resistance rate was 78.95% and the acquired multidrug resistance rate was 42.11%. Conclusion The initial rate of TB drug resistance in Ningbo is at a high level, and TB control in the city should be further strengthened.