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目的观察眼内期视网膜母细胞瘤患儿接受化学减容治疗的疗效。方法对2000年1月至2004年12月间于中山眼科中心行化学减容治疗眼内期视网膜母细胞瘤的9例患儿10只眼进行观察分析。其中男性5例,女性4例;单侧1例,双侧8例。首次就诊时平均年龄为31个月(11~95个月),首次化疗时平均年龄为36.1个月(11~97个月)。结果5只眼(5例患者)化疗效果较好,化疗结束后基底直径平均减少了31.1%(-0.2%~59.3%),厚度平均减少了50.6%(28.6%~83.2%),其中1例在化疗结束18个月后肿瘤复发行眼球摘除,其余4例随访至今(平均20个月)无复发及转移。4只眼在治疗中肿瘤持续长大或出现新的病灶而行摘除眼球;1例因出现脑转移在化疗2个疗程后死亡。眼球保留率为40%。所有9例患者可耐受化疗引起的副作用,无严重并发症发生。结论化学减容对眼内期视网膜母细胞瘤有一定的疗效,是一种有潜力的保守治疗方法。
Objective To observe the curative effect of chemical reduction treatment in children with intraocular retinoblastoma. Methods Nine eyes of 9 children with intravitreous retinoblastoma underwent chemical reduction at Zhongshan Ophthalmic Center from January 2000 to December 2004 were observed and analyzed. Including 5 males and 4 females; unilateral in 1 case, bilateral in 8 cases. The mean age at first visit was 31 months (range, 11-95 months), with an average of 36.1 months (range, 11-97 months) at the first chemotherapy. Results Five patients (5 patients) had good chemotherapeutic effect. The average diameter of the basilar membrane was reduced by 31.1% (-0.2% -59.3%) after chemotherapy and the average thickness was reduced by 50.6% (28.6% -83.2%). One case At 18 months after the end of chemotherapy, the tumor recurred with eyeball removal, and the remaining 4 patients were followed up (mean 20 months) without recurrence and metastasis. 4 eyes in the treatment of cancer continued to grow or appear new lesions line removal of the eye; 1 case of brain metastases in chemotherapy after 2 courses of death. Eyeball retention rate of 40%. All nine patients tolerated chemotherapy-induced side effects without serious complications. Conclusion Chemical reduction has some curative effect on intraocular retinoblastoma, which is a potential conservative treatment.