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近年研究表明不仅胚胎干细胞、胚胎性腺和皮肤细胞能分化产生卵母细胞,而且成年骨髓干细胞能表达生殖干细胞的标志基因、移植雌鼠骨髓细胞可使不育的受体卵巢中重新出现卵母细胞和卵泡,卵巢表面上皮细胞能形成生殖细胞样细胞,并分化为透明带蛋白阳性的卵母细胞和组装形成新的初级卵泡,以及胰腺干细胞也能诱导出现干细胞标志物、生殖细胞标志物以及减数分裂标志基因表达,产生卵母细胞样细胞,但是这些新产生的卵母细胞是否有正常功能受到质疑,卵母细胞生成调控的分子基础正在进一步探索之中。
In recent years, studies have shown that not only embryonic stem cells, embryonic gonads and skin cells can differentiate to produce oocytes, but also adult bone marrow stem cells can express germline stem cell marker gene. Transplantation of female rat bone marrow cells can reappear oocytes in sterile ovary And follicles, ovarian surface epithelial cells can form germ cell-like cells and differentiate into zona pellucida-positive oocytes and assemble to form new primary follicles, and pancreatic stem cells can also induce the appearance of stem cell markers, germ cell markers, and However, whether these newly produced oocytes have normal functions is questioned, and the molecular basis of oocyte production regulation is under further exploration.